Symptomatic CNS Radiation Necrosis Requiring Neurosurgical Resection During Treatment with Lorlatinib in ALK-Rearranged NSCLC: A Report of Two Cases

Central nervous system (CNS) metastasis carries a significant morbidity and mortality in anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). Next-generation ALK tyrosine kinase inhibitors (TKIs) are highly CNS-penetrant and have demonstrated remarkable intracranial activi...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Lung Cancer (Auckl)
Autori principali: Zhu, Viola W, Nagasaka, Misako, Kubota, Takafumi, Raval, Kunil, Robinette, Natasha, Armas, Octavio, Al-Holou, Wajd, Ou, Sai-Hong Ignatius
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove 2020
Soggetti:
Case Series
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6970251/
https://ncbi.nlm.nih.gov/pubmed/32021525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/LCTT.S224991
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