Symptomatic CNS Radiation Necrosis Requiring Neurosurgical Resection During Treatment with Lorlatinib in ALK-Rearranged NSCLC: A Report of Two Cases

Central nervous system (CNS) metastasis carries a significant morbidity and mortality in anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). Next-generation ALK tyrosine kinase inhibitors (TKIs) are highly CNS-penetrant and have demonstrated remarkable intracranial activi...

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Detalhes bibliográficos
Publicado no:Lung Cancer (Auckl)
Main Authors: Zhu, Viola W, Nagasaka, Misako, Kubota, Takafumi, Raval, Kunil, Robinette, Natasha, Armas, Octavio, Al-Holou, Wajd, Ou, Sai-Hong Ignatius
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
Assuntos:
Case Series
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6970251/
https://ncbi.nlm.nih.gov/pubmed/32021525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/LCTT.S224991
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