Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2

Insig-2 is an ER membrane protein negatively controlling lipid biosynthesis. Here, we find that Insig-2 is increased in the tissues, including liver, but unaltered in the muscle of gp78-deficient mice. In hepatocytes and undifferentiated C2C12 myoblasts, Insig-2 is ubiquitylated on Cys215 by gp78 an...

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Publicat a:Nat Commun
Autors principals: Zhou, Zhang-Sen, Li, Mei-Xin, Liu, Jie, Jiao, Hengwu, Xia, Jing-Ming, Shi, Xiong-Jie, Zhao, Huabin, Chu, Liping, Liu, Jingrong, Qi, Wei, Luo, Jie, Song, Bao-Liang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969111/
https://ncbi.nlm.nih.gov/pubmed/31953408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14231-w
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