Cryo-EM structure of the respiratory syncytial virus RNA polymerase

The respiratory syncytial virus (RSV) RNA polymerase, constituted of a 250 kDa large (L) protein and tetrameric phosphoprotein (P), catalyzes three distinct enzymatic activities — nucleotide polymerization, cap addition, and cap methylation. How RSV L and P coordinate these activities is poorly unde...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Cao, Dongdong, Gao, Yunrong, Roesler, Claire, Rice, Samantha, D’Cunha, Paul, Zhuang, Lisa, Slack, Julia, Domke, Mason, Antonova, Anna, Romanelli, Sarah, Keating, Shayon, Forero, Gabriela, Juneja, Puneet, Liang, Bo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969064/
https://ncbi.nlm.nih.gov/pubmed/31953395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14246-3
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