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An ultra-stable cytoplasmic antibody engineered for in vivo applications
Targeting cytoplasmic protein–protein interactions with antibodies remains technically challenging, since antibodies expressed in the cytosol frequently form insoluble aggregates. Existing engineering methods are based on the notion that the estimated net charge at pH 7.4 affects stability; as such,...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6969036/ https://ncbi.nlm.nih.gov/pubmed/31953402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13654-9 |
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