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Bacterial Hsp70 resolves misfolded states and accelerates productive folding of a multi-domain protein

The ATP-dependent Hsp70 chaperones (DnaK in E. coli) mediate protein folding in cooperation with J proteins and nucleotide exchange factors (E. coli DnaJ and GrpE, respectively). The Hsp70 system prevents protein aggregation and increases folding yields. Whether it also enhances the rate of folding...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Imamoglu, Rahmi, Balchin, David, Hayer-Hartl, Manajit, Hartl, F. Ulrich
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969021/
https://ncbi.nlm.nih.gov/pubmed/31953415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14245-4
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