Evaluation of the genomic alterations in the androgen receptor gene during treatment with high-dose testosterone for metastatic castrate-resistant prostate cancer

Introduction: Castration resistant prostate cancer (CRPC) has been characterized by a reactivation of the androgen receptor (AR) signaling pathway via alterations in androgen metabolism and AR aberrations. High-dose testosterone (HDT) is emerging as an active treatment in metastatic CRPC, however, b...

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Vydáno v:Oncotarget
Hlavní autoři: Moses, Marcus, Koksal, Ulkuhan, Ledet, Elisa, Manogue, Charlotte, Cotogno, Patrick, Lewis, Brian, Layton, Jodi, Sartor, A. Oliver, Barata, Pedro
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2020
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6967778/
https://ncbi.nlm.nih.gov/pubmed/32002120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27408
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