A Phase 1b Study of Vismodegib with Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

INTRODUCTION: Components of the hedgehog signaling pathway are upregulated in patients with idiopathic pulmonary fibrosis (IPF). Vismodegib, a small-molecule inhibitor of hedgehog signaling, when used in combination with currently available antifibrotic therapy, may be more efficacious than antifibr...

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Pubblicato in:Pulm Ther
Autori principali: Prasse, Antje, Ramaswamy, Murali, Mohan, Shaun, Pan, Lin, Kenwright, Andrew, Neighbors, Margaret, Belloni, Paula, LaCamera, Peter P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Healthcare 2019
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6967289/
https://ncbi.nlm.nih.gov/pubmed/32026407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s41030-019-0096-8
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