Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca(2+)/calpain might contribute to postoperative cognitive dysfunction in aging mice

BACKGROUND: Postoperative cognitive decline (POCD) is a recognized clinical phenomenon characterized by cognitive impairments in patients following anesthesia and surgery, yet its underlying mechanism remains unclear. Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal plast...

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Udgivet i:J Neuroinflammation
Main Authors: Qiu, Li-Li, Pan, Wei, Luo, Dan, Zhang, Guang-Fen, Zhou, Zhi-Qiang, Sun, Xiao-Yun, Yang, Jian-Jun, Ji, Mu-Huo
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966800/
https://ncbi.nlm.nih.gov/pubmed/31948437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1695-x
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