ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output

Melanoma and non-small-cell lung carcinoma (NSCLC) cell lines are characterized by an intrinsic population of cancer stem-like cells (CSC), and high expression of detoxifying isozymes, the aldehyde dehydrogenases (ALDHs), regulating the redox state. In this study, using melanoma and NSCLC cells, we...

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Publicado en:Cancers (Basel)
Main Authors: Terzuoli, Erika, Bellan, Cristiana, Aversa, Sara, Ciccone, Valerio, Morbidelli, Lucia, Giachetti, Antonio, Donnini, Sandra, Ziche, Marina
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966589/
https://ncbi.nlm.nih.gov/pubmed/31817719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121963
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