The α9 Nicotinic Acetylcholine Receptor Mediates Nicotine-Induced PD-L1 Expression and Regulates Melanoma Cell Proliferation and Migration

Cigarette smoking is associated with an increased risk of melanoma metastasis. Smokers show higher PD-L1 expression and better responses to PD-1/PD-L1 inhibitors than nonsmokers. Here, we investigate whether nicotine, a primary constituent of tobacco, induces PD-L1 expression and promotes melanoma c...

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Udgivet i:Cancers (Basel)
Main Authors: Nguyen, Hai Duong, Liao, You-Cheng, Ho, Yuan-Soon, Chen, Li-Ching, Chang, Hui-Wen, Cheng, Tzu-Chun, Liu, Donald, Lee, Woan-Ruoh, Shen, Shing-Chuan, Wu, Chih-Hsiung, Tu, Shih-Hsin
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966517/
https://ncbi.nlm.nih.gov/pubmed/31835799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121991
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