Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity

Background: Pediatric high-grade gliomas (pHGGs) are facing a very dismal prognosis and representative pre-clinical models are needed for new treatment strategies. Here, we examined the relevance of collecting functional, genomic, and metabolomics data to validate patient-derived models in a hypoxic...

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Pubblicato in:Cancers (Basel)
Autori principali: Blandin, Anne-Florence, Durand, Aurélie, Litzler, Marie, Tripp, Aurélien, Guérin, Éric, Ruhland, Elisa, Obrecht, Adeline, Keime, Céline, Fuchs, Quentin, Reita, Damien, Lhermitte, Benoit, Coca, Andres, Jones, Chris, Lelong Rebel, Isabelle, Villa, Pascal, Namer, Izzie Jacques, Dontenwill, Monique, Guenot, Dominique, Entz-Werle, Natacha
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966513/
https://ncbi.nlm.nih.gov/pubmed/31779235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121875
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