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Vienna LiverTox Workspace—A Set of Machine Learning Models for Prediction of Interactions Profiles of Small Molecules With Transporters Relevant for Regulatory Agencies

Transporters expressed in the liver play a major role in drug pharmacokinetics and are a key component of the physiological bile flow. Inhibition of these transporters may lead to drug-drug interactions or even drug-induced liver injury. Therefore, predicting the interaction profile of small molecul...

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Bibliografiske detaljer
Udgivet i:Front Chem
Main Authors: Montanari, Floriane, Knasmüller, Bernhard, Kohlbacher, Stefan, Hillisch, Christoph, Baierová, Christine, Grandits, Melanie, Ecker, Gerhard F.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966498/
https://ncbi.nlm.nih.gov/pubmed/31998690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00899
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