Integrated Two‐Analyte Population Pharmacokinetic Model of Polatuzumab Vedotin in Patients With Non‐Hodgkin Lymphoma

A two‐analyte integrated population pharmacokinetic (PK) model that simultaneously describes concentrations of antibody‐conjugated monomethyl auristatin E (acMMAE) and unconjugated MMAE following repeated administrations of polatuzumab vedotin (pola) was developed based on data from four clinical st...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Lu, Dan, Lu, Tong, Gibiansky, Leonid, Li, Xiaobin, Li, Chunze, Agarwal, Priya, Shemesh, Colby S., Shi, Rong, Dere, Randall C., Hirata, Jamie, Miles, Dale, Chanu, Pascal, Girish, Sandhya, Jin, Jin Yan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966185/
https://ncbi.nlm.nih.gov/pubmed/31749251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12482
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