Inactivation of 3-hydroxybutyrate dehydrogenase type 2 promotes proliferation and metastasis of nasopharyngeal carcinoma by iron retention

BACKGROUND: 3-Hydroxybutyrate dehydrogenase type 2 (BDH2) is known to catalyse a rate-limiting step in the biogenesis of the mammalian siderophore and regulate intracellular iron metabolism. Here we aim to explore the expression and possible function of BDH2 in nasopharyngeal carcinoma (NPC). METHOD...

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Veröffentlicht in:Br J Cancer
Hauptverfasser: Li, Bo, Liao, Zhipeng, Mo, Yingxi, Zhao, Weilin, Zhou, Xiaohui, Xiao, Xiling, Cui, Wanmeng, Feng, Guofei, Zhong, Suhua, Liang, Yushan, Du, Chunping, Huang, Guangwu, Li, Ping, Xiao, Xue, Zhou, Xiaoying, Wang, Rensheng, Zhang, Zhe
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964698/
https://ncbi.nlm.nih.gov/pubmed/31819181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0638-8
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