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Extension of the 5-alkynyluridine side chain via C–C-bond formation in modified organometallic nucleosides using the Nicholas reaction

Dicobalt hexacarbonyl nucleoside complexes of propargyl ether or esters of 5-substituted uridines react with diverse C-nucleophiles. Synthetic outcomes confirmed that the Nicholas reaction can be carried out in a nucleoside presence, leading to a divergent synthesis of novel metallo-nucleosides enri...

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Bibliographic Details
Published in:Beilstein J Org Chem
Main Authors: Kaczmarek, Renata, Korczyński, Dariusz, Green, James R, Dembinski, Roman
Format: Artigo
Language:Inglês
Published: Beilstein-Institut 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964655/
https://ncbi.nlm.nih.gov/pubmed/31976010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.16.1
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