Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos

This study evaluates the embryotoxicity of dithienylethene-modified peptides upon photoswitching, using 19 analogues based on the β-hairpin scaffold of the natural membranolytic peptide gramicidin S. We established an in vivo assay in two variations (with ex vivo and in situ photoisomerization), usi...

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Bibliographic Details
Published in:Beilstein J Org Chem
Main Authors: Afonin, Sergii, Babii, Oleg, Reuter, Aline, Middel, Volker, Takamiya, Masanari, Strähle, Uwe, Komarov, Igor V, Ulrich, Anne S
Format: Artigo
Language:Inglês
Published: Beilstein-Institut 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964649/
https://ncbi.nlm.nih.gov/pubmed/31976015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.16.6
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