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Simvastatin inhibits inflammatory response in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages through the microRNA-22/Cyr61 axis

Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has been shown to improve atherosclerosis (AS) via its anti-inflammatory activity. Recently, several studies have reported the involvement of macrophages in chronic inflammation associated with AS. However, it is unk...

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Pubblicato in:Int J Clin Exp Pathol
Autori principali: Hu, Tianran, Chen, Bingxu, Zhou, Shengheng, Mao, Jialiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962815/
https://ncbi.nlm.nih.gov/pubmed/31949780
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