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Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury

The immune system monitors the health of cells and is stimulated by necrosis. Here we examined the receptors and ligands driving this response. In a targeted screen of C-type lectin receptors, a Clec2d reporter responded to lysates from necrotic cells. Biochemical purification identified histones, b...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Lai, Jiann-Jyh, Cruz, Freidrich M., Rock, Kenneth L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962543/
https://ncbi.nlm.nih.gov/pubmed/31859049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.11.013
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