Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment

Altered metabolism in pulmonary artery smooth muscle cells (PASMCs) and endothelial cells (PAECs) contributes to the pathology of pulmonary hypertension (PH), but changes in substrate uptake and how substrates are utilized have not been fully characterized. We hypothesized stable isotope metabolomic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hernandez-Saavedra, Daniel, Sanders, Linda, Freeman, Scott, Reisz, Julie A., Lee, Michael H., Mickael, Claudia, Kumar, Rahul, Kassa, Biruk, Gu, Sue, Alessandro, Angelo D’, Stenmark, Kurt R., Tuder, Rubin M., Graham, Brian B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962446/
https://ncbi.nlm.nih.gov/pubmed/31942023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-57200-5
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