Lysophosphatidylcholine Induces NLRP3 Inflammasome-Mediated Foam Cell Formation and Pyroptosis in Human Monocytes and Endothelial Cells

Foam cells are specialized lipid-loaded macrophages derived from monocytes and are a key pathological feature of atherosclerotic lesions. Lysophosphatidylcholine (LPC) is a major lipid component of the plasma membrane with a broad spectrum of proinflammatory activities and plays a key role in athero...

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Vydáno v:Front Immunol
Hlavní autoři: Corrêa, Rafael, Silva, Luís Felipe Fonseca, Ribeiro, Dalila Juliana Silva, Almeida, Raquel das Neves, Santos, Igor de Oliveira, Corrêa, Luís Henrique, de Sant'Ana, Lívia Pimentel, Assunção, Leonardo Santos, Bozza, Patrícia T., Magalhães, Kelly Grace
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962110/
https://ncbi.nlm.nih.gov/pubmed/31998284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02927
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