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The Epstein–Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization

Epstein–Barr virus (EBV) immortalizes human B-lymphocytes and is implicated in the pathogenesis of lymphoid and epithelial cell malignancies. The EBV nuclear antigen (EBNA)-1 induces the accumulation of reactive oxygen species (ROS), which enables B-cell immortalization but causes oxidative DNA dama...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Wang, Jiayu, Nagy, Noemi, Masucci, Maria G.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962091/
https://ncbi.nlm.nih.gov/pubmed/31511648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-1003-3
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