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Neutrophil-targeted, protease-activated pulmonary drug delivery blocks airway and systemic inflammation

Pulmonary drug delivery presents a unique opportunity to target lower airway inflammation, which is often characterized by the massive recruitment of neutrophils from blood. However, specific therapies are lacking modulation of airway neutrophil function, and difficult challenges must be overcome to...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Mejías, Joscelyn C., Forrest, Osric A., Margaroli, Camilla, Frey Rubio, David A., Viera, Liliana, Li, Jindong, Xu, Xin, Gaggar, Amit, Tirouvanziam, Rabindra, Roy, Krishnendu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962027/
https://ncbi.nlm.nih.gov/pubmed/31661469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131468
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