MEK1 regulates pulmonary macrophage inflammatory responses and resolution of acute lung injury

The MEK1/2–ERK1/2 pathway has been implicated in regulating the inflammatory response to lung injury and infection, and pharmacologic MEK1/2 inhibitor compounds are reported to reduce detrimental inflammation in multiple animal models of disease, in part through modulation of leukocyte responses. Ho...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Long, Matthew E., Gong, Ke-Qin, Eddy, William E., Volk, Joseph S., Morrell, Eric D., Mikacenic, Carmen, West, T. Eoin, Skerrett, Shawn J., Charron, Jean, Liles, W. Conrad, Manicone, Anne M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962022/
https://ncbi.nlm.nih.gov/pubmed/31801908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132377
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