ER stress and Rho kinase activation underlie the vasculopathy of CADASIL

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) leads to premature stroke and vascular dementia. Mechanism-specific therapies for this aggressive cerebral small vessel disease are lacking. CADASIL is caused by NOTCH3 mutations that influence vascu...

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Enregistré dans:
Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Neves, Karla B., Harvey, Adam P., Moreton, Fiona, Montezano, Augusto C., Rios, Francisco J., Alves-Lopes, Rhéure, Nguyen Dinh Cat, Aurelie, Rocchicciolli, Paul, Delles, Christian, Joutel, Anne, Muir, Keith, Touyz, Rhian M.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962020/
https://ncbi.nlm.nih.gov/pubmed/31647781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131344
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