Cooperation between Constitutive and Inducible Chemokines Enables T-cell Engraftment and Immune Attack in Solid Tumors

We investigated the role of chemokines in regulating T-cell accumulation in solid tumors. CCL5 and CXCL9 overexpression was associated with CD8(+) T-cell infiltration in solid tumors. T-cell infiltration required tumor cell-derived CCL5 and was amplified by IFNγ-inducible, myeloid cell-secreted CXCL...

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Veröffentlicht in:Cancer Cell
Hauptverfasser: Dangaj, Denarda, Bruand, Marine, Grimm, Alizée J., Ronet, Catherine, Barras, David, Duttagupta, Priyanka A., Lanitis, Evripidis, Duraiswamy, Jaikumar, Tanyi, Janos L., Benencia, Fabian, Conejo-Garcia, Jose, Ramay, Hena R., Montone, Kathleen T., Powell, Daniel J., Gimotty, Phyllis A., Facciabene, Andrea, Jackson, Donald G., Weber, Jeffrey S., Rodig, Scott J., Hodi, Stephen F., Kandalaft, Lana E., Irving, Melita, Zhang, Lin, Foukas, Periklis, Rusakiewicz, Sylvie, Delorenzi, Mauro, Coukos, George
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961655/
https://ncbi.nlm.nih.gov/pubmed/31185212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.05.004
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