Inhibition of protein FAK enhances 5-FU chemosensitivity to gastric carcinoma via p53 signaling pathways

The small molecule drug 5-fluorouracil (5-FU) is widely used in the treatment for gastric cancer (GC), however, it exerts poor efficacy and is associated with acquired and intrinsic resistance. Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, plays a key role in adhesion, migration, and...

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Udgivet i:Comput Struct Biotechnol J
Main Authors: Hou, Jingjing, Tan, Yuyu, Su, Chen, Wang, Tao, Gao, Zhixing, Song, Dan, Zhao, Jiabao, Liao, Yueting, Liu, Xiaotian, Jiang, Ying, Feng, Qian, Wan, Zhong, Yu, Yongsheng
Format: Artigo
Sprog:Inglês
Udgivet: Research Network of Computational and Structural Biotechnology 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961071/
https://ncbi.nlm.nih.gov/pubmed/31969973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2019.12.010
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