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A Novel Hybrid CNN-SVR for CRISPR/Cas9 Guide RNA Activity Prediction

Accurate prediction of guide RNA (gRNA) on-target efficacy is critical for effective application of CRISPR/Cas9 system. Although some machine learning-based and convolutional neural network (CNN)-based methods have been proposed, prediction accuracy remains to be improved. Here, firstly we improved...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Zhang, Guishan, Dai, Zhiming, Dai, Xianhua
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6960259/
https://ncbi.nlm.nih.gov/pubmed/31969902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.01303
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