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The ETFL formulation allows multi-omics integration in thermodynamics-compliant metabolism and expression models

Systems biology has long been interested in models capturing both metabolism and expression in a cell. We propose here an implementation of the metabolism and expression model formalism (ME-models), which we call ETFL, for Expression and Thermodynamics Flux models. ETFL is a hierarchical model formu...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Salvy, Pierre, Hatzimanikatis, Vassily
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959363/
https://ncbi.nlm.nih.gov/pubmed/31937763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13818-7
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