Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients

The sarcomeric troponin-tropomyosin complex is a critical mediator of excitation-contraction coupling, sarcomeric stability and force generation. We previously reported that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients with a dilated cardiomyopathy (DCM) mutation, tr...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Dai, Yuanyuan, Amenov, Asset, Ignatyeva, Nadezda, Koschinski, Andreas, Xu, Hang, Soong, Poh Loong, Tiburcy, Malte, Linke, Wolfgang A., Zaccolo, Manuela, Hasenfuss, Gerd, Zimmermann, Wolfram-Hubertus, Ebert, Antje
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959358/
https://ncbi.nlm.nih.gov/pubmed/31937807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56597-3
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