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Targeting the RhoGTPase/ROCK pathway for the treatment of VHL/HIF pathway-driven cancers
The loss of the von Hippel-Lindau (VHL) tumor-suppressor is a major driver of Clear Cell Renal Cell Carcinoma (CC-RCC) resulting in the stabilization and overactivation of hypoxia inducible factors (HIFs). ROCK1 is a well-known protein serine/threonine kinase which is recognized as having a role in...
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| Pubblicato in: | Small GTPases |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6959287/ https://ncbi.nlm.nih.gov/pubmed/28632992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2017.1336193 |
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