Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension

Chronic hypoxia leads to pathologic remodeling of the pulmonary vasculature and pulmonary hypertension (PH). The antioxidant enzyme extracellular superoxide dismutase (SOD3) protects against hypoxia-induced PH. Hyaluronan (HA), a ubiquitous glycosaminoglycan of the lung extracellular matrix, is rapi...

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Publicat a:Sci Rep
Autors principals: Tseng, Victor, Ni, Kevin, Allawzi, Ayed, Prohaska, Clare, Hernandez-Lagunas, Laura, Elajaili, Hanan, Cali, Valbona, Midura, Ronald, Hascall, Vincent, Triggs-Raine, Barbara, Petrache, Irina, Hart, C. Michael, Nozik-Grayck, Eva
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959284/
https://ncbi.nlm.nih.gov/pubmed/31937874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-57147-7
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