Non-genotoxic MDM2 inhibition selectively induces a pro-apoptotic p53 gene signature in chronic lymphocytic leukemia cells

Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous hematologic malignancy. In approximately 90% of cases the TP53 gene is in its wildtype state at diagnosis of this malignancy. As mouse double-minute-2 homolog (MDM2) is a primary repressor of p53, targeting this protein is an attractiv...

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Pubblicato in:Haematologica
Autori principali: Ciardullo, Carmela, Aptullahoglu, Erhan, Woodhouse, Laura, Lin, Wei-Yu, Wallis, Jonathan P, Marr, Helen, Marshall, Scott, Bown, Nick, Willmore, Elaine, Lunec, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959162/
https://ncbi.nlm.nih.gov/pubmed/31004033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.206631
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