Pyruvate dehydrogenase kinase 1 interferes with glucose metabolism reprogramming and mitochondrial quality control to aggravate stress damage in cancer

Pyruvate dehydrogenase kinase 1 (PDK1) is a key factor in the connection between glycolysis and the tricarboxylic acid cycle. Restoring the mitochondrial OXPHOS function by inhibiting glycolysis through targeting PDK1 has become a hot spot for tumor therapy. However, the specific mechanism by which...

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Vydáno v:J Cancer
Hlavní autoři: Deng, Xinyue, Wang, Quan, Cheng, Meiyu, Chen, Yingying, Yan, Xiaoyu, Guo, Rui, Sun, Liankun, Li, Yang, Liu, Yanan
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959030/
https://ncbi.nlm.nih.gov/pubmed/31949499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.34330
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