DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing—a possible predictive biomarker for malignant transformation

BACKGROUND: DNA hypermethylation of tumor suppressor genes is observed in precancerous lesions and oral cancer of individuals with the habits of betel quid (BQ) chewing. SIRT1 has been identified as playing a role in the maintenance of epithelial integrity, and its alteration is often related to car...

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Veröffentlicht in:Clin Epigenetics
Hauptverfasser: Islam, Shajedul, Uehara, Osamu, Matsuoka, Hirofumi, Kuramitsu, Yasuhiro, Adhikari, Bhoj Raj, Hiraki, Daichi, Toraya, Seiko, Jayawardena, Asiri, Saito, Ichiro, Muthumala, Malsantha, Nagayasu, Hiroki, Abiko, Yoshihiro, Chiba, Itsuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6958620/
https://ncbi.nlm.nih.gov/pubmed/31931863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0806-y
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