GDF11 ameliorated myocardial ischemia reperfusion injury by antioxidant stress and up-regulating autophagy in STZ-induced type 1 diabetic rats

PURPOSE: To investigate whether GDF11 ameliorates myocardial ischemia reperfusion (MIR) injury in diabetic rats and explore the underlying mechanisms. METHODS: Diabetic and non-diabetic rats subjected to MIR (30 min of coronary artery occlusion followed by 120 min of reperfusion) with/without GDF11...

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Veröffentlicht in:Acta Cir Bras
Hauptverfasser: Bin, Zhou, Yanli, Yu, Zhen, Qiu, Qingtao, Meng, Zhongyuan, Xia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6958563/
https://ncbi.nlm.nih.gov/pubmed/31939595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/s0102-865020190110000006
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