Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation

BACKGROUND & AIMS: Ral guanosine triphosphatase–activating protein α2 (RalGAPα2) is the major catalytic subunit of the negative regulators of the small guanosine triphosphatase Ral, a member of the Ras subfamily. Ral regulates tumorigenesis and invasion/metastasis of some cancers; however, the r...

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Bibliografiske detaljer
Udgivet i:Cell Mol Gastroenterol Hepatol
Main Authors: Iida, Tomoya, Hirayama, Daisuke, Minami, Naoki, Matsuura, Minoru, Wagatsuma, Kohei, Kawakami, Kentaro, Nagaishi, Kanna, Nojima, Masanori, Ikeuchi, Hiroki, Hirota, Seiichi, Shirakawa, Ryutaro, Horiuchi, Hisanori, Nakase, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957823/
https://ncbi.nlm.nih.gov/pubmed/31622786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.10.003
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