Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis

Growth and Differentiation Factor 5 (GDF5) is a key risk locus for osteoarthritis (OA). However, little is known regarding regulation of Gdf5 expression following joint tissue damage. Here, we employed Gdf5-LacZ reporter mouse lines to assess the spatiotemporal activity of Gdf5 regulatory sequences...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kania, Karolina, Colella, Fabio, Riemen, Anna H. K., Wang, Hui, Howard, Kenneth A., Aigner, Thomas, Dell’Accio, Francesco, Capellini, Terence D., Roelofs, Anke J., De Bari, Cosimo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957535/
https://ncbi.nlm.nih.gov/pubmed/31932746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-57011-8
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