PTEN deletion drives aberrations of DNA methylome and transcriptome in different stages of prostate cancer

PTEN is a tumor suppressor gene and one of the most frequently mutated/deleted genes in human prostate cancer (PCa). However, how PTEN deletion would impact the epigenome and transcriptome alterations remain unknown. This hypothesis was tested in a prostate-specific PTEN−/− (KO) mouse prostatic aden...

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Publicat a:FASEB J
Autors principals: Wang, Chao, Feng, Yaping, Zhang, Chengyue, Cheng, David, Wu, Renyi, Yang, Yuqing, Sargsyan, Davit, Kumar, Dibyendu, Kong, Ah-Ng
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956734/
https://ncbi.nlm.nih.gov/pubmed/31914691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201901205RR
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