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Epimers Switch Galectin-9 Domain Selectivity: 3N-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal

[Image: see text] A series of 3-deoxy-3-N-arylated-β-d-galactoside and -guloside derivatives have been synthesized by cesium fluoride/trimetylsilylaryl triflate-mediated benzyne generation and N-arylation of 3-deoxy-3-amino-β-d-galactosides and -gulosides, respectively. Evaluation as ligands to gale...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Mahanti, Mukul, Pal, Kumar Bhaskar, Sundin, Anders P., Leffler, Hakon, Nilsson, Ulf J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956361/
https://ncbi.nlm.nih.gov/pubmed/31938460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00396
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