Bedaquiline, pretomanid and linezolid for treatment of extensively drug resistant, intolerant or non-responsive multidrug resistant pulmonary tuberculosis

BACKGROUND: Patients with extensively drug resistant tuberculosis (TB) have limited treatment options with historically poor outcomes. We investigated treatment with 3 oral drugs, bedaquiline (B), pretomanid (Pa) and linezolid (L), (B-Pa-L), with TB bactericidal activity and little pre-existing resi...

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Udgivet i:N Engl J Med
Main Authors: Conradie, Francesca, Diacon, Andreas H, Ngubane, Nosipho, Howell, Pauline, Everitt, Daniel, Crook, Angela M, Mendel, Carl M, Egizi, Erica, Moreira, Joanna, Timm, Juliano, McHugh, Timothy D, Wills, Genevieve, Bateson, Anna, Hunt, Robert, Van Niekerk, Christo, Li, Mengchun, Olugbosi, Morounfolu, Spigelman, Melvin
Format: Artigo
Sprog:Inglês
Udgivet: Massachusetts Medical Society 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955640/
https://ncbi.nlm.nih.gov/pubmed/32130813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1901814
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