Amino Acid Mutations A286V and T437M in the Nucleoprotein Attenuate H7N9 Viruses in Mice

The low-pathogenic H7N9 influenza viruses that emerged in 2013 acquired an insertion of four amino acids in their hemagglutinin cleavage site and thereby became highly pathogenic to chickens in 2017. Previous studies indicated that these highly pathogenic H7N9 viruses are virulent in chickens but ha...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Ma, Shujie, Zhang, Bo, Shi, Jianzhong, Yin, Xin, Wang, Guangwen, Cui, Pengfei, Liu, Liling, Deng, Guohua, Jiang, Yongping, Li, Chengjun, Chen, Hualan
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955278/
https://ncbi.nlm.nih.gov/pubmed/31666373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01530-19
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