Design of a programmable biosensor-CRISPRi genetic circuits for dynamic and autonomous dual-control of metabolic flux in Bacillus subtilis

Dynamic regulation is an effective strategy for fine-tuning metabolic pathways in order to maximize target product synthesis. However, achieving dynamic and autonomous up- and down-regulation of the metabolic modules of interest simultaneously, still remains a great challenge. In this work, we creat...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Wu, Yaokang, Chen, Taichi, Liu, Yanfeng, Tian, Rongzhen, Lv, Xueqin, Li, Jianghua, Du, Guocheng, Chen, Jian, Ledesma-Amaro, Rodrigo, Liu, Long
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Synthetic Biology and Bioengineering
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954435/
https://ncbi.nlm.nih.gov/pubmed/31799627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1123
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