Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria

BACKGROUND: Optimal anti-bacterial activity of meropenem requires maintenance of its plasma concentration (Cp) above the minimum inhibitory concentration (MIC) of the pathogen for at least 40% of the dosing interval (fT > MIC > 40). We aimed to determine whether a 3-h extended infusion (EI) of...

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Dettagli Bibliografici
Pubblicato in:Ann Intensive Care
Autori principali: Kothekar, Amol T., Divatia, Jigeeshu Vasishtha, Myatra, Sheila Nainan, Patil, Anand, Nookala Krishnamurthy, Manjunath, Maheshwarappa, Harish Mallapura, Siddiqui, Suhail Sarwar, Gurjar, Murari, Biswas, Sanjay, Gota, Vikram
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954163/
https://ncbi.nlm.nih.gov/pubmed/31925610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13613-019-0622-8
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