A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy

Enhancing natural killer (NK) cell cytotoxicity by blocking inhibitory signaling could lead to improved NK-based cancer immunotherapy. Thus, we have developed a highly efficient method for editing the genome of human NK cells using CRISPR/Cas9 to knock out inhibitory signaling molecules. Our method...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Pomeroy, Emily J., Hunzeker, John T., Kluesner, Mitchell G., Lahr, Walker S., Smeester, Branden A., Crosby, Margaret R., Lonetree, Cara-lin, Yamamoto, Kenta, Bendzick, Laura, Miller, Jeffrey S., Geller, Melissa A., Walcheck, Bruce, Felices, Martin, Webber, Beau R., Starr, Timothy K., Moriarity, Branden S.
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2020
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6953961/
https://ncbi.nlm.nih.gov/pubmed/31704085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.10.009
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