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The Integrator complex attenuates promoter-proximal transcription at protein-coding genes

The transition of RNA polymerase II (Pol II) from initiation to productive elongation is a central, regulated step in metazoan gene expression. At many genes, Pol II pauses stably in early elongation, remaining engaged with the 25-60 nucleotide-long nascent RNA for many minutes while awaiting signal...

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Bibliografski detalji
Izdano u:Mol Cell
Glavni autori: Elrod, Nathan D., Henriques, Telmo, Huang, Kai-Lieh, Tatomer, Deirdre C., Wilusz, Jeremy E., Wagner, Eric J., Adelman, Karen
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952639/
https://ncbi.nlm.nih.gov/pubmed/31809743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.034
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