Bile acid bio-nanoencapsulation improved drug targeted-delivery and pharmacological effects via cellular flux: 6-months diabetes preclinical study

The antilipidemic drug, probucol (PB), has demonstrated potential applications in Type 2 diabetes (T2D) through its protective effects on pancreatic β-cells. PB has poor solubility and bioavailability, and despite attempts to improve its oral delivery, none has shown dramatic improvements in absorpt...

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Publicado en:Sci Rep
Autores principales: Mooranian, Armin, Raj Wagle, Susbin, Kovacevic, Bozica, Takechi, Ryu, Mamo, John, Lam, Virginie, Watts, Gerald F., Mikov, Momir, Golocorbin-Kon, Svetlana, Stojanovic, Goran, Al-Sallami, Hesham, Al-Salami, Hani
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952395/
https://ncbi.nlm.nih.gov/pubmed/31919411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53999-1
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