Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice

Late onset Alzheimer’s disease (LOAD) is a progressive neurodegenerative disease with four well-established risk factors: age, APOE4 genotype, female chromosomal sex, and maternal history of AD. Each risk factor impacts multiple systems, making LOAD a complex systems biology challenge. To investigat...

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Udgivet i:PLoS One
Main Authors: Shang, Yuan, Mishra, Aarti, Wang, Tian, Wang, Yiwei, Desai, Maunil, Chen, Shuhua, Mao, Zisu, Do, Loi, Bernstein, Adam S., Trouard, Theodore P., Brinton, Roberta D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952084/
https://ncbi.nlm.nih.gov/pubmed/31917799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0225392
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