Impact of Disease and Treatment Response in Drug–Drug Interaction Studies: Osimertinib and Simvastatin in Advanced Non‐Small Cell Lung Cancer

A phase I, open‐label study (NCT02197234) assessed the effects of osimertinib on simvastatin exposure in patients with advanced epidermal growth factor receptor (EGFR)‐mutated non‐small cell lung cancer and disease progression post‐EGFR tyrosine kinase inhibitor treatment. Here, we report on a retro...

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Foilsithe in:Clin Transl Sci
Main Authors: Vishwanathan, Karthick, Cantarini, Mireille, So, Karen, Masson, Eric, Fetterolf, Jennifer, Ramalingam, Suresh S., Harvey, R. Donald
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2019
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6951454/
https://ncbi.nlm.nih.gov/pubmed/31498564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12688
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