miR‐181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart

BACKGROUND: Translocation of miR‐181c into cardiac mitochondria downregulates the mitochondrial gene, mt‐COX1. miR‐181c/d(−/−) hearts experience less oxidative stress during ischemia/reperfusion (I/R) and are protected against I/R injury. Additionally, miR‐181c overexpression can increase mitochondr...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Am Heart Assoc
Autori principali: Banavath, Hemanth N., Roman, Barbara, Mackowski, Nathan, Biswas, Debjit, Afzal, Junaid, Nomura, Yohei, Solhjoo, Soroosh, O'Rourke, Brian, Kohr, Mark, Murphy, Elizabeth, Steenbergen, Charles, Das, Samarjit
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6951067/
https://ncbi.nlm.nih.gov/pubmed/31801413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.012919
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi