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Newly Discovered Action of HpTx3 from Venom of Heteropoda venatoria on Na(v)1.7 and Its Pharmacological Implications in Analgesia

It has been reported that Heteropodatoxin3 (HpTx3), a peptidic neurotoxin purified from the venom of the spider species Heteropoda venatoria, could inhibit K(v)4.2 channels. Our present study newly found that HpTx3 also has potent and selective inhibitory action on Na(v)1.7, with an IC(50) of 135.61...

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Detalles Bibliográficos
Publicado en:Toxins (Basel)
Autores principales: Wu, Xinzhou, Wang, Zhouquan, Chen, Yu, Xu, Dehong, Zhang, Peng, Wang, Xianchun
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6950750/
https://ncbi.nlm.nih.gov/pubmed/31757020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins11120680
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